Patricia Arquette (born on April 8, 1968 in Chicago, Illinois) is an American film actress.

Arquette is of Jewish and distant French descent. She is the daughter of the late actor Lewis Arquette, and granddaughter of the late comic Cliff Arquette. She is sister to the actors Rosanna Arquette, David Arquette, and Alexis Arquette. She is the sister-in-law of Courteney Cox Arquette, who is married to her brother David.

She was married to Academy Award-winning actor Nicolas Cage from 1995 until 2001. She and fellow actor Thomas Jane are the parents of a baby girl named Harlow Olivia Calliope, born February 20, 2003.

She won an Emmy Award for Outstanding Lead Actress in 2005 for her role as the psychic Allison DuBois on NBC's Medium.