Patricia Arquette (born on April 8, 1968 in Chicago, Illinois) is an American film actress.

Arquette is of Jewish and distant French descent. She is the daughter of the late actor Lewis Arquette, and granddaughter of the late comic Cliff Arquette. She is sister to the actors Rosanna Arquette, David Arquette, and Alexis Arquette. She is the sister-in-law of Courteney Cox Arquette, who is married to her brother David.