Laura San Giacomo (born November 14, 1962) is an Italian-American actress.

San Giacomo was born in New Jersey and attended Washington College and the Carnegie Mellon School of Drama. She has appeared in the films Sex, Lies, and Videotape (1989), Pretty Woman (1990), Quigley Down Under (1990), and Nina Takes a Lover (1994), among others. She was the lead character as the feminist Maya Gallo in the sitcom Just Shoot Me (1997-2003) and did voice work for the animated series Gargoyles. She was to have made her return to television on The WB's new drama Related in 2005, but the character she was to play was recast due to creative differences. Laura made her first public appearance in nearly a year on October 19, 2005. Laura made an appearance at the 15th Annual Environmental Media Awards.