Karen Valentine (born May 25, 1947 in Sebastopol, California) is an Emmy Award winning American actress, best known for her role as Alice Johnson in the TV series Room 222.

In 1967 she married David Ross Williams, to whom she was married for two years.

She first won a spot representing California at the Miss Teenage America pageant. When Ed Sullivan saw her talent act, he was quoted as saying "I want that girl on my show." Her break on Room 222 followed shortly thereafter.

She later starred as Gidget in the film Gidget Grows Up, and on her own television series in 1975, Karen. Valentine was also a regular on Hollywood Squares, often trading quips and giggles with Paul Lynde. Though her star faded after the 1980s, she continues to work, and as recently as 2004, she co-starred with John Larroquette in a Hallmark TV movie called Wedding Daze.

She is of Italian and Portuguese descent.