Janeane Garofalo (born September 28, 1964 in Newton, New Jersey), is an American stand-up comedian, actress, political activist, and radio host on Air America Radio.

Garofalo's father is an Italian American former executive named Carmine Garofalo and her Irish American mother Joan, who died of cancer, was once a secretary. During high school, her family relocated to Houston, Texas, where the trauma of the move prompted her famously self-loathing acerbic persona to begin to blossom. While studying history at Providence College, Garofalo entered a comedy talent search sponsored by the Showtime cable network, winning the title of "Funniest Person in Rhode Island." Her original gimmick was to read off of her hand, which was not successful in subsequent performances. Dreaming of earning a slot on the writing staff of the Late Night With David Letterman program, she became a professional standup upon graduating college with degrees in History and American Studies but struggled for a number of years, working briefly as a bike messenger in Boston.

The winner of numerous comedy awards and recognitions, she officially began her career in stand-up comedy in the late 1980s during the grunge era. Her appearance was often in line with grunge style: disheveled with thick black glasses and unkempt hair. Her comedy is often self-deprecating; she made fun of popular culture and the pressures put on women to live up to media-created body ideals.

Garofalo is a self-described pessimist: "I guess I just prefer to see the dark side of things. The glass is always half empty. And cracked. And I just cut my lip on it. And chipped a tooth."

Garofalo's comedy shows involve her and her notebook, which is filled with years' worth of article clippings and random observations that she uses for reference during her act for direct quotes, as with new articles, and to enhance the unprepared, fully conversational nature of her standup. Garofalo feels she does not tell jokes but makes observations and hopefully gets laughs.

Garofalo and comedian Marc Maron helped organize the weekly alternative "Eating It" standup comedy show, with different line-ups each week, which played for years at the Luna Lounge in New York's Lower East Side before the bar was finally razed. Later Garofalo and Maron would work together again to create a liberal radio network.

In April 2004 she was selected as #99 on Comedy Central's list of the 100 greatest standups of all time.

Her television series debut was on the short-lived The Ben Stiller Show on Fox in 1992, on which she was a cast member alongside longtime friends Ben Stiller, Bob Odenkirk, Andy Dick, and David Cross (who was a bit player). A chance meeting on the set of the show led her to be offered the role of Paula on The Larry Sanders Show on HBO, earning her two Emmy Award nominations in 1996 and 1997.

Following The Ben Stiller Show's cancellation, Garofalo joined the cast of Saturday Night Live in its ill-fated 1994-95 season. As detailed in Tom Shale's book Live from Saturday Night and mentioned in Jay Mohr's Gasping for Airtime : Two Years in the Trenches of Saturday Night Live Upon arrival at the show, she gave an interview in which she called fellow cast member Adam Sandler's comedy "childish." Writers on the show expressed dismay at what they perceived as Garofalo's negative attitude towards the show. According to them, Garofalo was insecure, tearing everyone else down to bring herself up, and she rarely assisted in writing sketches, never doing an "all-nighter" for a skit as many crewmembers did. The bitter atmosphere caused extreme discomfort and unhappiness for Garofalo and the show itself, and she left in January 1995, mid-season. She claimed that the reason for leaving was weak material and a sexist attitude on the show. The material on SNL at this time was mediocre, and other writers, such as Bruce Vilanch, have stated in interviews that many male members of the show frown upon women and homosexuals.

Garofalo has been offered many television series roles but has accepted few; for instance, she turned down the role of Monica, a role written with her or her type in mind and for which she was the first actress offered, on the hit NBC sitcom Friends. Two Garofalo-starring television pilots, an ABC show called Slice O'Life, in 2003, about a reporter sentenced to sappy human interest stories that appear at the end of news broadcast, and an NBC program called All In, in 2005, based on the family life and professional successes of poker star Annie Duke, were not picked up by their respective networks.

Throughout the 2005-2006 television season Garofalo appeared on The West Wing as a controversial campaign adviser to the fictional Democratic presidential nominee. Garofalo notably participated in the series' first live episode, most of which was a debate televised live on the east coast and then reshot live for the west. Garofalo's character seen walking backstage with her advisee before the start of each debate

Garofalo's first critically-acclaimed starring role in film was in 1996 in The Truth About Cats and Dogs, a variation of Cyrano which featured Uma Thurman in the top-billed but smaller role as a beautiful but vapid model, while Garofalo played a highly intelligent radio host. Initally an independent film, it became a studio film when Uma Thurman was signed to play the vapid model. The film was a modest hit, but to this day, Garofalo detests the film, calling it anti-feminist. Based on the success of this film, director Cameron Crowe then offered her a crack at the leading lady part in Jerry Maguire with Tom Cruise if she could lose weight, but after trimming down, she learned that Renee Zellweger had won the role instead. The mid-1990s were what Garofalo has termed the height of her popularity. Before The Truth About Cats and Dogs, she was visible from television work and memorable supporting roles in films such as Reality Bites, Bye Bye Love and Now and Then and a leading role in I Shot a Man in Vegas. Garofalo has had a variety of leading, supporting, and cameo roles in films as diverse as Steal This Movie, Cop Land, Dog Park, Wet Hot American Summer, Clay Pigeons, Southland Tales, The MatchMaker, Sweethearts, 200 Cigarettes, Romy and Michelle's High School Reunion, Dogma, The Cable Guy, Permanent Midnight, Duane Hopwood, Mystery Men, The Search for John Gissing, The Wild and Wonderland, among others.

Garofalo has been open and outspoken regarding her liberal political views, appearing in the past with figures such as Ralph Nader (whom she supported in 2000, but opposed in 2004) and Jello Biafra at events, while expressing feminist views in interviews throughout her career.

She became more prominent as an activist when she voiced opposition to what became the 2003 Iraq War, appearing on CNN and Fox News to discuss it. She said that she was approached by groups such as MoveOn.org and Win Without War to go on TV, because these organizations claim that the networks weren't allowing antiwar voices to be heard. Garofalo and the other celebrities who appeared at the time said they thought their fame could lend attention to a side they believed was being ignored by the corporate media. Her appearances on cable news prior to the war garnered her praise from the left and spots on the cover of Ms. and Venus magazines. Garofalo has had frequent on-air political disputes with Bill O'Reilly, Brian Kilmeade and Jonah Goldberg.

In March 2003, she took part in the Code Pink antiwar march in Washington, D.C. That fall, she served as mc at several stops on the "Tell Us the Truth" tour, a political-themed concert series featuring Steve Earle, Billy Bragg, Tom Morello, and others. Throughout the year, Garofalo also actively campaigned for Howard Dean.

In late March 2004 she became a co-host for Air America Radio's new show The Majority Report alongside Sam Seder. Garofalo once said getting on the radio was an early career goal of hers. A program advertisement: "The battle to reclaim America from the forces of darkness continues with hosts Janeane Garofalo and Sam Seder." The early days of Air America Radio are chronicled in the documentary Left of the Dial, which includes a debate between Janeane and her conservative father Carmine, who was initially a regular guest on The Majority Report.