Jacquetta Wheeler (born 16 October 1981 in London, England) is a fashion model.

Her father Stuart was an entrepreneur and her mother Tessa was a photographer, both of them successful in their careers. Wheeler lived a comfortable, moderately affluent lifestyle with her family. At the age of fifteen, she was discovered by Italian fashion designer Stephan Jansen. Jansen asked Wheeler to go to Milan and be in his fashion show. Later that year she was stopped in England on her way to a salon by fashion photographer Mario Testino. By the age of seventeen, she was on the face of French Vogue magazine and part of the Gucci campaign.

Although she continued to go to school at The King's School, Canterbury, in Luxmoore House, she'd often take off days to shoot for Calvin Klein, Prada and The Gap. In 1999 the magazine The Face called her the "Model of the Millennium". Designers loved her angrogynous, melancholy waif look.

In 2002 The Sunday Times named her one of Britain's highest paid supermodels. She had a long list of clients ranging from Burberry to Versace.

Jacquetta lives in New York and is romantically involved with Russian photographer Alexi Lubomirski.