Halle Berry was named after Halle's Department Store, a local landmark in her birthplace of Cleveland, Ohio. She is the daughter of Judith Ann Hawkins, a caucasian of English ancestry, and Jerome J. Berry, who is African-American. Berry's maternal grandmother, Nellie Dicken, was born in Sawley, Derbyshire, England, while her maternal grandfather, Earl Ellsworth Hawkins, was born in Ohio. Berry's parents divorced when she was 4 years old and she subsequently was raised by her mother, a psychiatric-ward nurse. She also has an older sister, Heidi.

Berry was a popular student at Bedford High School and was a cheerleader, honor society member, editor of the school newspaper, class president and prom queen. She worked in the children's department at Higbee's Department Store. Her personality, as described by a co-worker, was expressed in these terms..."I can hardly believe how sweet and nice she had been to everyone. People who weren't half as beautiful as she did not display the kind of inner beauty she exhibited." She subsequently attended Cuyahoga Community College.