Mac and Me is a 1988 family movie about a paraplegic boy and an extraterrestrial. The decision to create it was based largely on the success of E.T. (1982). The title itself, Mac and Me, comes from the working title for E.T. — E.T. and Me.

A Mysterious Alien Creature (MAC) trying to escape from NASA is befriended by a young boy in a wheel chair. Together, they try and find MAC's family from whom he has been separated.

The film is known for its numerous and blatant product placements, including Coca-Cola, Skittles, Sears and McDonald's (the main character's name, Mac, is an acronym for Mysterious Alien Creature, however, it is also a reference to McDonald's Big Mac sandwich). The aliens need only to drink Coke and eat Skittles to live. A ten minute impromptu dance number takes place in a McDonald's franchise, prompting Leonard Maltin to call the film "more like a TV commercial than a movie". However, according to Seth Stevenson, "there was no quid pro quo between the filmmakers and these companies." In spite of this, during the scene where Mac's baby is drinking a Coca-Cola, director Stewart Raffill comedically holds up four $100 bills in the background.

Mac and Me grossed $6,424,112 in the United States. The movie ends with a freeze frame and the words "We'll be back!" superimposed, but after its dismal box office returns any planned sequel was shelved. It was rated PG for violence in the United States by the MPAA.

Despite being labeled one of the worst movies ever by both IMDB and Rotten Tomatoes (0% "fresh"), Mac and Me has gained a cult following, due in large part to its low-grade production values. An example of which is the bad sound dubbing at one point. During the Sears scene while Eric's mother is riding the escalator, her line is dubbed, "Excuse me. I'll be right back." However, her mouth says the dialogue line "Excuse me, I'll be back in a minute."

The film has gained a measure of notoriety recently thanks to actor Paul Rudd, who, as part of a running gag from appearances on Late Night With Conan O'Brien, will frequently show the infamous clip of the wheelchair-bound Eric (Jade Calegory) flying off a cliff, while Mac watches on, instead of showing clips from the actual movie Rudd is there to promote. Within the clip of the cliff scene, Calegory's part was obviously taken by a mannequin; later chase scenes that show him skitching appear to have been done by Calegory himself, possibly at low speed with the action sped up in the final print.