Harley Davidson and the Marlboro Man is a 1991 action film, starring Mickey Rourke and Don Johnson. The film was written by Don Michael Paul and directed by Simon Wincer.

The film was a critical and financial failure, garnering many negative reviews and earning just over $7,000,000 at the domestic box office. The budget was estimated at $23,000,000.

Tagline: When the going gets tough... the tough take the law into their own hands.

Harley Davidson (Mickey Rourke) is in a motel in Texas when he hears about a dangerous new street drug named "Crystal Dream" on the radio. The significance of this street drug does not arise again until later in the film. Harley then meets a friend, a cowboy nicknamed The Marlboro Man (Don Johnson) and they plan a bank robbery to help save their friend's bar from being torn down and replaced with a skyscraper. However, after they rob a bank's armored car, they discover the cargo they stole is the designer drug "Crystal Dream", not money. Chance Wilder (Tom Sizemore), who is a bank president involved in drug dealing, demands the return of the drugs. A series of increasingly deadly encounters ensue as heavily-armed drug gang members hunt for Harley and Marlboro. The movie is known for a scene where Bon Jovi's Dead or Alive is played to an extended scene of Rourke travelling across the country on his Harley Davidson with desert scenery.