Garfield: A Tail of Two Kitties (also known as Garfield: The Movie 2 or its working title Garfield 2) is a theatrical sequel to the 2004 live-action feature film Garfield: The Movie. This film was directed by Tim Hill, written by Joel Cohen, produced by Davis Entertainment for 20th Century Fox, and was released in U.S. cinemas on June 16, 2006 (July 21, 2006 in UK). It borrows the concept of The Prince and the Pauper.

This film was rated PG by the MPAA for some off-color elements.

Garfield (voiced by Bill Murray) goes to the United Kingdom with canine sidekick Odie to surprise his master, Jon Arbuckle (Breckin Meyer), who is in London to propose to his girlfriend, veterinarian Dr. Liz Wilson (Jennifer Love Hewitt). Garfield switches places with Prince, a royal cat who has just inherited a castle.

In the grand estate Garfield now calls home, he receives the royal treatment, including a butler and an international array of four-legged servants and followers. Lord Dargis, who is next in line to inherit the estate, wants Prince/Garfield out of the picture.

The critical reaction to Garfield: A Tail Of Two Kitties had 88% of critics offering negative reviews on rottentomatoes.com. The film has made more in foriegn markets than domestic, as was expected based on the gross of the first Garfield.

As of September 17, 2006, Garfield: A Tail Of Two Kitties has earned to the date more than $28,403,409 in the U.S. Box Office, but overseas has earned more than $98,609,549 million making a total of $127,013,068 worldwide. Also in China, it holds the record for Biggest Opening for an Animated Movie.

The DVD is scheduled to release on October 10th, 2006. This DVD will include a "Drawing with Jim Davis" featurette and two games: "Garfield's Maze", and "Odie's Photo Album". It will also include a music video and trailers.