Eat Me, Drink Me is Marilyn Manson's sixth studio album, released worldwide on June 5, 2007. Eat Me, Drink Me was recorded in a rented home-recording studio in Hollywood, California by lead vocalist Marilyn Manson and guitarist and bassist Tim Sköld. A press-conference with Manson in April 2007 revealed that the album itself was a collaboration strictly between himself and Tim Sköld, causing speculation as to who performed the apparent drum and keyboard duties. It was produced by Marilyn Manson and Tim Sköld, and mixed by Sean Beavan. It has been stated that there were originally around 20 embryonic songs, all written by Sköld, 2 of which (that didn't make the album) Manson considered complete with lyrics and vocals. Manson stated that he had a difficult time cutting some of them, but felt he had to in order to prevent the album from being "diluted". It was released in two versions: a standard and a special collector's edition on June 5, 2007.

I feel as if there's more like three albums' worth of material, [because] I don't want to cram a long record into a place that doesn't have the attention span for that. . . I'd like to return to the old-fashioned records that had eight or nine songs [that] were all very important. Not to say that I made records that had filler material. They were all based around a central idea, and the central idea in this one is my pain and its ability to be unashamed to repeat itself. „
—Marilyn Manson, MTV News

[The songs] are clearly written to seduce somebody. . . I don't want people to think that the record is some kind of exploitation of my personal life. At the same time, it also represents exactly who I am and what I feel. . . I really wanted to be a singer on this album. This is very earnest and uncalculated and raw, in the sense that I know I'm fucked up, and I'm really not ashamed of it. „
—Marilyn Manson, Rolling Stone

This is the record I've worked all my life to get to. You always have to transform, or you can't continue as an artist, and this record has been the biggest transformation for me. . . It's better heard than described. . . On this record I really wanted to sing, and that has to come from a naked, emotional place. It's not a record about me crying, or songs about my woes, but I think this record will probably speak to more people in different ways, because of its total human element. . . If I had to do a record review, I'd say it's got a cannibal, consumption, obsessive, violent-sex, romance angle, but with an upbeat swing to it. . . The album's title [Eat Me, Drink Me] was also inspired by that story several years back of the German man who put out an ad that he wanted to be eaten, and the man who ate him. Although I can't relate to the relationship those two had, I found the story very compelling in a romantic way. I think a lot of people wouldn’t look at it as romantic, but it was to them in some sick way, and it is to me in some sick way, too. „
—Marilyn Manson, Revolver

The singer also referred to the album as "very guitar-oriented and very melodic", "takes a totally different approach musically" and as featuring "various unconventional forms of percussion". He has also called it a romantic album, in which the lyrical content involves "the unfulfilled yearning to be in another time or another place where you feel like you would fit in better".

In October 2005, the album was being referred to as 'nearly finished'. In a brief Rolling Stone interview nearly a year later, Manson referred to "about half an album's worth of tracks"; it is unknown whether previously-recorded material was scrapped, or whether any additional work had been completed on the album since 2005. In mid-October, 2006, the singer again told an interviewer that the album was "almost done now".

At the October 31, 2006, opening of his Los Angeles, California, art gallery, Manson spoke again with Rolling Stone, saying "the process of opening a gallery ended up inspiring me to make a new record. . . we're about two songs away from a finished album that we didn't even have a few months ago. It sounds rather pretentious sometimes, but it's easier for me to just call myself an artist — if I decide to do music or if I decide to do a film, it works. I just want to uphold a level of integrity".

On January 19, 2007, the official Marilyn Manson website formally disclosed the album's title as Eat Me, Drink Me, a title which may be interpreted to hold several meanings, not the least of which are obvious references to Alice's Adventures in Wonderland and the Eucharist. Manson says the album's title was also inspired by "that story several years back of the German man who put out an ad that he wanted to be eaten, and the man who ate him. Although I can't relate to the relationship those two had, I found the story very compelling in a romantic way. I think a lot of people wouldn't look at it as romantic, but it was to them in some sick way, and it is to me in some sick way, too." The cannibalism story is that of Armin Meiwes.

On February 26, 2007, MarilynManson.com revealed the opinion of Rolling Stone upon first hearing the album as being:

Things got really interesting on Saturday when the Smoking Section drove out to the Valley at the behest of Marilyn Manson. The S.S. joined Manson in his rec room where we worked our way down the belly of a bottle of German absinth and were blown away as Manson debuted his new album, Eat Me, Drink Me. The key cut is "If I Was Your Vampire," a six-minute epic with the lyric "The hole is where the heart is." If anyone thought Manson was down for the count, think again. „
—Austin Scaggs, Rolling Stone

On March 8, 2007, The Heirophant reported that the Eat Me, Drink Me's release date had been pushed to June 2007. On March 10, 2007, The Heirophant reported a recent Rolling Stone interview with Manson, where he talks about his experiences the past year and describes some songs from the upcoming album by name. In the May 2007 issue of Revolver Manson gave additional descriptions of the tracks he mentioned in his March 10 interview with Rolling Stone. He also gave his input on the album.

In the April issue of RockMag, a March 14 listening party from the magazine reported the first seven tracks up to about thirty-three minutes into the album. Worth noting was their report of a track called "I'm Not Your Vampire" which is very similar to "If I Was Your Vampire". The track has even been described on the lines of what Rolling Stone described to be "If I Was Your Vampire".

On April 4, 2007 The Heirophant announced the official track listing for Eat Me, Drink Me, a total of eleven tracks. Worth noting was the difference between the first seven tracks of the official track listing, compared to the first seven tracks described in the April issue of RockMag. This leads to speculation that the RockMag listening party listened to a seven-track sampler of the album and not literally the first seven tracks of the official disc. Rolling Stone later confirmed the track listing. The album is currently set for a June 5, 2007 release, as of April.

On April 11, 2007, the French fansite MansonLegion.com posted an exclusive track-by-track review of the complete album, unlike the previous review by RockMag detailing seven tracks from a sampler of the record. The English-translated review was posted on The Heirophant on the same day.

On April 12, 2007, a press-conference with Marilyn Manson was conducted, in which he stated the album itself has been a collaboration strictly between himself and Tim Skold. Manson has also said that Tim Skold will be the live guitarist for the upcoming tour in June, while the new live bassist is Rob Holliday from The Prodigy. In an exclusive interview with The Heirophant, Manson also revealed that Chris Vrenna (who had filled in as a temporary replacement drummer in 2004 for then-injured Ginger Fish), would be taking over keyboard duties on the tour. Manson cited Pogo's absence as being due to his own "personal issues".

On April 16, 2007, "If I Was Your Vampire" was made available for streaming on the Marilyn Manson's newly created official MySpace account. Also revealed was the album's cover art that appeared in the player. Hours later the cover art was confirmed in an Interscope press release sent to select music distributors.

On April 18, 2007 Marilyn Manson opened an official account on VampireFreaks.com, probably in order to promote the album's running "vampire" theme to a suitable community.

On May 18, 2007, the official booklet of Eat Me, Drink Me was posted on Marilyn Manson's official website in its entirety.

Recently, an official Eat Me, Drink Me mini-site was discovered through a link found in the Europe "Heart-Shaped Glasses (When the Heart Guides the Hand)" single. The site contains lyrics, an art gallery, a mosaic, and the ability to stream up to two tracks per day starting on May 28, 2007. Upon completion of the mosaic, an Eat Me, Drink Me wallpaper becomes available for download, and three preview tracks ("Heart-Shaped Glasses (When the Heart Guides the Hand)", "If I Was Your Vampire", and "Evidence") become available for streaming.

On May 23, 2007, Marilyn Manson and Tim Skold appeared on UK radio station Radio 1 to discuss Eat Me, Drink Me, and performed two acoustic songs; one a rendition of "Heart-Shaped Glasses (When the Heart Guides the Hand)" and the other a Justin Timberlake cover titled "What Goes Around... Comes Around".[

On May 31, 2007, the entire album was made available via MySpace. It was later pulled off when the album was released.

On May 1, 2007, the entire album was leaked onto several peer-to-peer networks. In a speculated response to the leak, Marilyn Manson commissioned DJ Ryan Manno on Q101 in Chicago to play the entire album on their radio station at 11:00 PM the following night.

On March 27, 2007, Charts in France reported that James Cameron was filming a new music video with Marilyn Manson called "When the Heart Guides the Hand", which will use a special effect in 3D. The Heirophant reported that it is planned to be released on DVD, and on March 28, 2007, The Heirophant also reported that Evan Rachel Wood and the SuicideGirls were to have been involved in the video as well.

On April 24, 2007, "Heart-Shaped Glasses (When the Heart Guides the Hand)" was added to the Marilyn Manson's official MySpace account.

On April 27, 2007 Marilyn Manson released a clip featuring the last 34 seconds of the then upcoming music video for "Heart-Shaped Glasses (When the Heart Guides the Hand)" on YouTube, and later on the official website. On May 8, 2007, the following week, the music video was world premiered on Sevenload.de. The song peaked at #24 on U.S. Modern Rock Tracks.